In vitro ADME Service
In order to understand and clarify a certain property of a drug and its correlation with drug efficacy and toxicity, many in vitro pharmacokinetics methods are effectively applied to drug metabolism and interaction evaluation, such as in vitro absorption model, in vitro liver system research, in vitro transport system, etc. These in vitro methodologies provide in vitro to in vivo inferences of the same species when inferring human pharmacokinetic parameters and characteristics. In vitro methodology can make up for the defects of animal methodology in experimental design by using different coenzymes, different selective inhibitors, and different recombinant gene pure enzymes. The application of in vitro pharmacokinetics, while not affecting or optimizing the amount of preclinical research information, reduces the use of experimental animals, making the implementation of animal ethics gradually feasible.
Overall Solutions
CD BioSciences specializes in providing customized in vitro kinetics services. We have more than ten years of experience in drug research and development and have professional knowledge in drug metabolism, pharmacokinetics, pharmacodynamic research, and toxicology. We are confident in providing you with high-quality data and quick turnaround to support various drug development, preclinical research and clinical research. Our services include but not limited to:
- Plasma protein binding studies.
- In vitro drug metabolism study: species differences of liver microsomes and hepatocytes, identification of CYP450 metabolic phenotype, identification of metabolites.
- Biomembrane permeability: Caco-2 cells, MDCK cells, parallel artificial membrane PAMPA.
- Drug interaction: CYP enzyme induction and enzyme inhibition.
Our Features
CD BioSciences has first-class R&D laboratories equipped with advanced scientific instruments. It has passed the International Laboratory Animal Assessment and Accreditation (AAALAC), and has reached the GLP standard of the U.S. Food and Drug Administration. The preclinical safety evaluation complies with the European Economic Cooperation and Development Organization (referred to as OECD) GLP specification.
Our Services
|
Project name |
In vitro ADME Service |
| Services |
- Drug metabolism stability and metabolite determination
- Drug distribution
- Drug-drug interaction
- Drug physical and chemical property analysis
- In vitro toxicity analysis
|
| Cycle |
To be decided according to your needs. |
| Product delivery mode |
Including final product delivery, electronic data report. In addition to the agreement, relevant electronic data will be provided together, including nuclear magnetic analysis, high performance liquid chromatography, mass spectrometry, gas chromatography, etc. |
| Price |
Inquiry |
Our Advantages
- Excellent service platform, professional technical team, and advanced instrument.
- We have established a professional after-sales service team to provide customers with efficient, fast and practical solutions.
- Leading technology, experienced and pioneering professional R&D team can meet the customized needs of new compounds from milligram level to kilogram level.
- High efficiency, fast response, flexible research direction, low price, short cycle and high quality.
Why Choose Us?
CD BioSciences' in vitro ADME service is a personalized and customized innovative scientific research service. Each project needs to be evaluated before the corresponding analysis plan and price can be determined. If you want to know more about service prices or technical details, please feel free to contact us.
