Pharmacokinetics Service
CD BioSciences' pharmacokinetics service consists of four areas: biological analysis, in vitro pharmacokinetics, in vivo pharmacokinetics, and toxicology. Our team of experts is led by scientists who have been employed in well-known international pharmaceutical companies, focusing on the scientific nature of pharmacokinetics experiments and the rigor of results, while emphasizing the application of the results of pharmacokinetics experiments to specific drug research and development projects. For many years, we have completed numerous R&D projects commissioned by many pharmaceutical and biotechnology companies.
Significance of Pharmacokinetics
With the development of medicinal chemistry and the continuous improvement of human health, the requirements for the pharmacokinetics properties of drugs are escalating. A drug's strong curative effect and small side effects are not enough for market approval unless good PK properties are demonstrated. Peptide drugs are the most typical example. In general, many biologically active peptides in the body, such as endorphins, have the characteristics of high efficiency and low toxicity, but they are unstable in vivo and ineffective in oral administration.
Overall Solutions
- CD BioSciences has accumulatively completed ADME in vitro screening tests and in vivo pharmacokinetics tests for tens of thousands of compounds for many customers around the world to support their early drug screening and development.
- Our DMPK department works closely with biology, pharmacology and antibody departments to apply early formulation development, in vitro and in vivo correlation, model analysis of pharmacodynamics, biomarker detection and metabolomics and other technologies in translational medicine research.
Our services include but not limited to：
In vivo metabolism
- Absorption, distribution, metabolism and excretion
- Intracorporal process of drugs and major PK parameters
- Bioavailability
- Bioequivalence
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In vitro metabolism
- Species variation in metabolism
- Drug-drug interactions
- Drug absorption and kinetics
- Protein binding
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Features of Pharmacokinetics
- On the one hand, the effect of drugs (medicinal effects, toxicity, or side effects) on the body is manifested in the pharmacological or toxicological effects of the drug, which is determined by a specific chemical structure and has strong structural specificity.
- The other aspect is the body's effects on drugs: absorption, distribution, biotransformation and excretion, which are manifested in the pharmacokinetics properties of drugs. It mainly depends on the drug's solubility, lipid-water partition coefficient, electric charge and other physical and chemical properties of the drug molecule as a whole, and its structural specificity is not strong.
Our Services
|
Project name |
Pharmacokinetics Service |
| Services |
- Pharmacokinetics
- Early toxicology determination
- Biomarker analysis
- Biological analysis of preclinical and clinical samples
- Macromolecular Pharmacokinetics/Bioanalysis Services
|
| Cycle |
To be decided according to your needs. |
| Product delivery mode |
Including final product delivery, electronic data report. In addition to the agreement, relevant electronic data will be provided together, including nuclear magnetic analysis, high performance liquid chromatography, mass spectrometry, gas chromatography, etc. |
| Price |
Inquiry |
Our Advantages
- Customized production procedures to help customers reduce capital and time costs.
- We have ample resources dedicated to helping accelerate your research timelines.
- We have first-class production equipment and a quality management system.
- Leading technology, experienced and pioneering professional R&D team can meet the customized needs of new compounds from milligram level to kilogram level.
- High efficiency, fast response, flexible research direction, low price, short cycle and high quality.
Why Choose Us?
CD BioSciences' pharmacokinetics service can be customized for innovative scientific research. Each project needs to be evaluated before the corresponding analysis plan and price can be determined. If you want to know more about service prices or technical details, please feel free to contact us.
